Thermo Fisher Scientific CDK12 Polyclonal Antibody

Thermo Fisher Scientific CDK12 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1:1,000–1:3,000

Publications

• [References available upon request]

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total CD2L7.

Target Information

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity but activates transcription upon formation of JUN or FOS heterodimers. Also binds TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities, possibly by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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