Thermo Fisher Scientific CD27 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total CD27.

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members regulate cell proliferation and death.
Expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High CD27 expression depends on proper ligation of antigen receptors, while CD70 expression requires additional co-stimulatory or pro-inflammatory signals.

CD27 exists as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. Activation of T cells via the TCR-CD3 complex upregulates CD27 expression and induces release of its soluble 28–32 kDa form (sCD27), detectable in plasma, urine, or spinal fluid. Soluble CD27 serves as an important prognostic marker in acute and chronic B cell malignancies.

RgpA, a cysteine proteinase, can degrade CD27 and counteract T cell activation mediated by CD27 and CD70. The CD27-binding protein SIVA, a proapoptotic molecule, binds to CD27 and contributes to apoptosis induced by this receptor.
Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.