Thermo Fisher Scientific CD48 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total CD48.

Target Information

CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily that includes CD2, CD58, CD84, CD150, CD229, CD244, and others. These molecules mediate homotypic or heterotypic adhesion by binding within the Ig family.
CD48 is a GPI-anchored protein expressed on hematopoietic cells and acts as a high-affinity ligand for 2B4 and a low-affinity ligand for CD2. The 2B4–CD48 interaction among NK and NK-T cells regulates cell proliferation.
Signaling through CD48 activates eosinophils, and CD48 expression increases in several infectious diseases. CD48 is strongly expressed on lymphocytes and monocytes, weakly on granulocytes, and absent on platelets, fibroblasts, epithelium, and endothelium.
It is a marker for detecting GPI anchoring defects in paroxysmal nocturnal hemoglobinuria (PNH) and may be involved in allergic airway disease pathology, providing a potential pharmacological target for allergic rhinitis and asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.