Thermo Fisher Scientific Phospho-BCR (Tyr177) Polyclonal Antibody
Phospho-BCR (Tyr177) 항체로 인간 및 생쥐 시료에서 인산화된 BCR 단백질 검출에 적합. Western blot과 유세포분석에 사용 가능하며, 항원 친화 크로마토그래피로 정제된 고품질 rabbit polyclonal antibody. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr177 of human Bcr |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 229 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981179 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein encoded by sequences from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear. The BCR protein exhibits serine/threonine kinase activity and functions as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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