Thermo Fisher Scientific PERK Polyclonal Antibody
Rabbit polyclonal antibody against human PERK (EIF2AK3). Validated for IHC (paraffin) at 1:200–1:500 dilution. Affinity purified, liquid form, unconjugated. Ideal for ER stress and protein synthesis pathway research.
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- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human EIF2AK3. Recombinant protein control fragment (Product #RP-90474) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789695 |
Product Specific Information
Immunogen sequence:
NAWLEAPPEK WQEKMDEIWL KDESTDWPLS SPSPMDAPSV KIRRMDPFAT KEHIEIIAPS PQRSRSFSVG ISCDQTSSSE SQFSPLEFSG MDHEDISESV DAAYNLQDSC LTDCDVEDGT MDGNDE
Target Information
EIF2AK3 (PERK) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to environmental stresses, leading to decreased protein synthesis. In EIF2AK3, signaling is triggered by misfolded proteins in the ER.
Defects in EIF2AK3 cause Wolcott-Rallison syndrome (WRS), a rare autosomal recessive disorder characterized by permanent neonatal or early infancy insulin-dependent diabetes, epiphyseal dysplasia, osteoporosis, growth retardation, and multisystem manifestations such as hepatic and renal dysfunctions, mental retardation, and cardiovascular abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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