Thermo Fisher Scientific UNC5CL Polyclonal Antibody
Human UNC5CL 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. NF-κB 관련 연구 및 세포 사멸 메커니즘 분석에 활용 가능.
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Thermo Fisher Scientific UNC5CL Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UNC5CL (Product #RP-90179) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2789694 |
Product Specific Information
Immunogen sequence:
MHTFQDGLET KYMEILRFQA SEEESWAAPP PVSQPPPCNR LPPELFEQLR MLLEPNSITG NDWRRLASHL GLCGMKIRFL SCQRSPAAAI LELFEEQNGS LQELHYLMTV MERLDCASAI QNYLSGTHGG SPGPERGGAR DNQGLELDEK
Target Information
UNC5CL is a membrane protein belonging to the UNC-5 family with a death domain and a ZU5 domain. It interacts with p65/RELA and NFKB1, and with subunit p105 of NF-kappaB and transactivator p65. UNC5CL inhibits NF-kappaB activation and NF-kappaB-dependent transcription by preventing NF-kappaB binding to its target sequence, providing an alternative regulatory mechanism for NF-kappaB-mediated transcription. This regulatory protein sensitizes cells to apoptosis induced by TNF and TRAIL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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