Thermo Fisher Scientific UNC5CL Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human UNC5CL. Recombinant protein control fragment (Product #RP-90179). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:UNC5CL,uniProtId:Q8IV45-1,ncbiNodeId:9606,antigenRange:368-517,antigenLength:518,antigenImageFileName:PA5-82536_UNC5CL_Q8IV45-1_Rabbit.svg,antigenImageFileNamePDP:PA5-82536_UNC5CL_Q8IV45-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789694

Product Specific Information

Immunogen sequence: MHTFQDGLET KYMEILRFQA SEEESWAAPP PVSQPPPCNR LPPELFEQLR MLLEPNSITG NDWRRLASHL GLCGMKIRFL SCQRSPAAAI LELFEEQNGS LQELHYLMTV MERLDCASAI QNYLSGTHGG SPGPERGGAR DNQGLELDEK

Target Information

UNC5CL is a membrane protein belonging to theUNC-5 family with a death domain and a ZU5 domain and is known to interact with p65/RELA and NFKB1. UNC5CL is known to interact with subunit p105 of NF-kappaB and transactivator p65 and is thus involved in inhibition of NF-kappaB activation and NF-kappaB-dependent transcription by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB-mediated transcription). This regulatory protein sensitizes cells to apoptosis induced by TNF and TRAIL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.