Thermo Fisher Scientific AR Monoclonal Antibody (OTI1D3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. This receptor (~90 kDa) contains three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.
AR acts as a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.

AR signaling is essential for the development and function of male reproductive organs (prostate, epididymis) and also influences nonreproductive tissues (muscle, hair follicles, brain).
It is a phosphoprotein that regulates MAP kinase pathways, and MEK1/2 inhibition affects AR phosphorylation.
Abnormal AR signaling is associated with diseases such as prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity syndrome (CAIS).

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.