Thermo Fisher Scientific CD19 Monoclonal Antibody (CB19)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: Assay-dependent

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

MA1-7638 detects CD19 from human samples.
MA1-7638 has been successfully used in flow cytometry, fluorescent microscopy, and Immunohistology (Frozen) procedures.
The MA1-7638 immunogen is a CD19 protein.

Target Information

CD19 is a member of the immunoglobulin superfamily and has two Ig-like domains.
The CD19 molecule is expressed on 100% of peripheral B cells as defined by expression of kappa or lambda light chains.
CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage.
Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen.
The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias.

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens.
The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors.
CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge.
Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.