Thermo Fisher Scientific H3R8me2a Polyclonal Antibody

Thermo Fisher Scientific H3R8me2a Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

This antibody reacts with human Histone H3.2.
A BLAST analysis suggests cross-reactivity with Human, Mouse, and C. elegans.
Predicted to react with Rat, Chicken, Xenopus, Drosophila, and Plant based on 100% sequence homology.
Cross-reactivity with Histone H3 from other sources has not been determined.

Target Information

Histones are basic nuclear proteins responsible for the nucleosome structure of chromosomal fiber in eukaryotes.
This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of H2A, H2B, H3, and H4.
The chromatin fiber is further compacted through interaction of linker histone H1 with DNA between nucleosomes to form higher-order chromatin structures.
The H3 gene is intronless, located on chromosome 1 within a histone cluster, and encodes a member of the histone H3 family.
Transcripts lack polyA tails and contain a palindromic termination element.
This record represents the telomeric copy of one of the duplicated histone genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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