Thermo Fisher Scientific UNG Polyclonal Antibody
Thermo Fisher Scientific의 UNG Polyclonal Antibody는 Human Uracil-DNA Glycosylase를 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 Immunoprecipitation에 사용 가능하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 263 and 313 of Human Uracil-DNA Glycosylase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These isoforms are generated by alternative splicing and two differentially regulated promoters (PA and PB). The cDNAs for UNG1 and UNG2 are similar in size (2061 and 2058 bp), and thus their mRNAs are not resolved as two species in gel electrophoresis.
Nuclear UNG2 differs from mitochondrial UNG1 by 44 amino acids at the N-terminal sequence, which is not required for catalytic activity. The UNG gene products play a major role in repairing mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues. Expression levels of UNG1 and UNG2 vary by cell and tissue type and are cell-cycle regulated. Generally, UNG expression and activity are higher in proliferating than in non-proliferating cells.
- UNG1: 304 amino acids
- UNG2: 313 amino acids
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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