Thermo Fisher Scientific IWS1 Polyclonal Antibody
IWS1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 IHC(Paraffin)에서 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%) 제품. RNA polymerase II 전사 복합체 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human IWS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720933 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
IWS1 is a transcription factor that plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and modulating the production of mature mRNA transcripts. It acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A).
The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone-modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export, and elongation-coupled H3K36 methylation, a chromatin mark of active transcription.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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