Thermo Fisher Scientific PRMT6 Polyclonal Antibody
PRMT6 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 인간 PRMT6의 C-말단 영역(325-375)을 면역원으로 사용하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 325 and the C-terminus (residue 375) of Human Protein Arginine Methyltransferase 6 (PRMT6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Bovine
Target Information
Protein arginine N-methyltransferase 6 (PRMT6) exhibits type I PRMT activity, forming omega-N monomethylarginine and asymmetric dimethylarginine derivatives on glycine- and arginine-rich substrates.
Acts as a transcriptional coactivator of steroid hormone receptors (ESR1, ESR2, PGR, NR3C1).
Promotes fasting-induced transcriptional activation of the gluconeogenic program via methylation of the CRTC2 transcription coactivator.
May contribute to innate immunity against HIV-1 by methylating and impairing the function of viral proteins such as Tat, Rev, and Nucleocapsid protein p7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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