Thermo Fisher Scientific B7-H3 Polyclonal Antibody
B7-H3(CD276)을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태이며, Human 시료에 반응. 면역조절 및 항암 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CD276. Recombinant protein control fragment (Product #RP-90039). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789731 |
Product Specific Information
Immunogen sequence:
EVQVPEDPVV ALVGTDATLC CSFSPEPGFS LAQLNLIWQL TDTKQLVHSF AEGQDQGSAY ANRTALFPDL LAQGNASLRL QRVRVADEGS FTCFVSIRDF G
Target Information
CD276, also known as B7-H3, is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that induces proliferation of CD4+ and CD8+ T cells, enhances cytotoxic T cell generation, and selectively stimulates interferon gamma production. Expression can be induced on dendritic cells and monocytes by inflammatory cytokines and is widely expressed in peripheral tissues such as heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing. It has therapeutic potential in regulating cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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