Thermo Fisher Scientific HnRNP Q Polyclonal Antibody
HnRNP Q 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin) 실험에 사용 가능. Human에 반응하며, mRNA 처리 및 안정성 연구에 적합. 2 mg/mL 농도의 액상 형태로 제공되며, 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 591–623 amino acids from the C-terminal region of human HNRPQ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2200597 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
Heterogeneous nuclear ribonucleoprotein (hnRNP) Q is implicated in mRNA processing mechanisms. It is a component of the CRD-mediated complex that promotes MYC mRNA stability. Isoforms 1, 2, and 3 are associated with pre-mRNA, splicing intermediates, and mature mRNA-protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences and participates in the APOB mRNA editosome complex, potentially modulating C-to-U RNA editing. It may also be involved in translationally coupled mRNA turnover and interacts with other RNA-binding proteins in mRNA decay processes. Isoform 3 may play a role in cytoplasmic vesicle-based mRNA transport via interaction with synaptotagmins. It is a component of the GAIT complex, which mediates interferon-gamma-induced transcript-selective translation inhibition during inflammation by binding to GAIT elements in 3'-UTR regions of inflammatory mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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