Thermo Fisher Scientific CD54 (ICAM-1) Monoclonal Antibody (RR1/1), FITC, eBioscience

Thermo Fisher Scientific CD54 (ICAM-1) Monoclonal Antibody (RR1/1), FITC, eBioscience

Applications

• Tested Application: Flow Cytometry
• Recommended Dilution: 10 µL/test
• Publications: View 3 publications

Product Specifications

Product Specific Information

• Recognizes the D1 domain of human CD54.
• ICAM-1 (Intercellular Adhesion Molecule-1) is a member of the immunoglobulin supergene family and acts as a ligand for LFA-1 (CD11a/CD18).
• Expressed on endothelial cells, epithelial cells, fibroblasts, macrophages, T-lymphoblasts, B cells, and dendritic cells.
• Inducible by inflammatory mediators such as IL-1, TNF, and IFN-γ.
• Elevated sICAM-1 levels are associated with inflammatory conditions including renal graft rejection and autoimmune diseases.
• Applications Tested: Flow Cytometry
• Purity: >95%
• Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser

Target Information

ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein with five immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail. It has seven potential N-linked glycosylation sites and shows homology with ICAM-2 and ICAM-3.
ICAM-1 binds to integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and serves as a receptor for rhinovirus.
It is expressed on activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, lymphocytes, monocytes, macrophages, dendritic cells, and neutrophils. Expression increases upon inflammation and is also observed in certain carcinoma and melanoma cells.
Soluble ICAM-1 is detectable in plasma and elevated in various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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