Thermo Fisher Scientific ITCH / AIP4 Polyclonal Antibody
Human ITCH 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot에 적합합니다. 합성 펩타이드 면역원 기반으로 제작되었으며, 1 mg/mL 농도의 액상 형태입니다. PBS와 50% glycerol 저장 buffer 포함, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ITCH (Accession Q96J02), corresponding to amino acid residues V394–W444 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900074 |
Product Specific Information
Antibody detects endogenous levels of total ITCH.
Target Information
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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