Thermo Fisher Scientific ERN1/ERN2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total IRE1.

Target Information

ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) is a protein-coding gene. Diseases associated with ERN1 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 5 and Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus.
Related pathways include Spinocerebellar ataxia and Photodynamic therapy-induced unfolded protein response.
Gene Ontology (GO) annotations include protein homodimerization activity and transferase activity transferring phosphorus-containing groups.
An important paralog of this gene is ERN2.
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1, which contains two functional catalytic domains — a serine/threonine-protein kinase domain and an endoribonuclease domain.
This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers the unfolded protein response (UPR), an ER stress response conserved from yeast to mammals.
The UPR activates genes involved in degrading misfolded proteins, regulating protein synthesis, and activating molecular chaperones.
This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
[Provided by RefSeq, Aug 2017]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.