Thermo Fisher Scientific MARK1 Polyclonal Antibody
MARK1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 최적화됨. Human, Mouse, Rat에서 반응하며, 세포극성 및 미세소관 관련 연구에 활용 가능. 항원 친화 크로마토그래피로 정제된 액상 시약으로, 연구용 전용.
- 판매단위
- pk
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Thermo Fisher Scientific MARK1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Ala547 of MARK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982571 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MARK1 (MARK) is a serine/threonine kinase involved in cytoskeletal organization and biogenesis. It plays a role in cell polarity by phosphorylating microtubule-associated proteins MAP2, MAP4, and MAPT/TAU at KXGS motifs, leading to their detachment and disassembly. MARK1 regulates neuronal migration through dual activities in cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. It also acts as a positive regulator of the Wnt signaling pathway, likely by mediating phosphorylation of dishevelled proteins (DVL1, DVL2, and/or DVL3).
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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