Thermo Fisher Scientific PYK2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with other related proteins.

Target Information

PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway.
PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, migration, adhesion, spreading, and bone remodeling.
FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells.
It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress.
Aberrant FAK2 expression may contribute to cancer cell proliferation, migration, and invasion. Elevated expression has been observed in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.