Thermo Fisher Scientific CD3 Monoclonal Antibody (7D6), PE-Cyanine7

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-Dependent
• Publications: View 2 publications

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• APC
• APC-Alexa Fluor 750
• FITC
• PE
• PE-Alexa Fluor 610
• PE-Alexa Fluor 700
• PE-Cyanine5.5
• PE-Texas Red
• TRI-COLOR
• Request custom conjugation

Product Specific Information

The R-phycoerythrin (PE)-Cy7 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a 488 nm laser without occupying traditional channels associated with FITC and PE.

Target Information

The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon, and CD3 zeta. These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.

The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules via a double tyrosine-based motif. CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum. It is not expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma, and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

Analyte Specific Reagent

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