Thermo Fisher Scientific CD3 Monoclonal Antibody (7D6)
Thermo Fisher Scientific의 CD3 Monoclonal Antibody (Clone 7D6)은 인간 CD3 epsilon을 타겟으로 하는 Mouse IgG2a 항체로, IHC 및 Flow Cytometry에 사용됩니다. 고순도 액상 형태로 제공되며 다양한 형광체 결합 옵션을 지원합니다. T세포 수용체 신호 전달 연구에 적합합니다.
- 카탈로그번호
- MHCD0300x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD3 Monoclonal Antibody (7D6)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | 1:20 | View 7 publications |
| Miscellaneous PubMed (Misc) | - | View 34 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7D6 |
| Immunogen | Human CD3 epsilon |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10372049 |
Available Conjugate Formats
- Alexa Fluor 488
- APC
- APC-Alexa Fluor 750
- FITC
- PE
- PE-Alexa Fluor 610
- PE-Alexa Fluor 700
- PE-Cyanine5.5
- PE-Cyanine7
- PE-Texas Red
- TRI-COLOR
- Request custom conjugation
Target Information
The CD3 subunit complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating the surface expression of the TCR complex. Activation of T cells through TCR involves CD3 gamma, delta, epsilon, and zeta subunits, which are structurally related members of the immunoglobulin superfamily encoded on human chromosome 11.
CD3 subunits have long cytoplasmic tails that interact with signal transduction molecules via a double tyrosine-based motif. CD3 plays roles in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells. Reduced T lymphocyte percentages may be observed in autoimmune diseases. Defects in the CD3 gene are linked to CD3 immunodeficiency.
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