Thermo Fisher Scientific Claudin 4 Polyclonal Antibody
Claudin 4 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간과 마우스 시료에서 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 접합부 연구 및 암 관련 단백질 발현 분석에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the internal segment of human Claudin 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Brain and Skeletal muscle
- Cellular location: Cellular junction, gap
Target Information
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux.
Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. Overexpression of Claudin-4 decreases paracellular electrical conductance due to a selective decrease in Na⁺ permeability, with no significant decrease in Cl⁻ permeability.
In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers.
The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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