Thermo Fisher Scientific ADRB1 Polyclonal Antibody

Thermo Fisher Scientific ADRB1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far, including three alpha-1 AR subtypes (1A/D, 1B, 1C), three alpha-2 ARs (2A, 2B, 2C), and three beta AR subtypes (1, 2, 3).

ARs are involved in several disease states such as hypertension, cardiac dysfunction, diabetes, glaucoma, depression, and impotence. Beta-1 adrenergic receptors (B1ARs) play roles in development, cardiac function, smooth muscle tone, and metabolism. Mice lacking the B1AR gene often die prenatally, and survivors exhibit abnormal cardiac function. Regulation of cardiac B1AR density by thyroid hormones occurs at the transcriptional level and is modulated by the catecholamine-sensitive adenylyl cyclase system. Evidence for cAMP effects on B1AR regulation involves CREM family transcription factors in transformed cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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