Thermo Fisher Scientific ADRB1 Polyclonal Antibody
ADRB1 단백질에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC, Flow, ELISA 등 다양한 실험에 사용 가능하며, 고순도 Protein A 정제 및 안정한 액상 형태로 제공됩니다.
- 카탈로그번호
- BS-0498R
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ADRB1 Polyclonal Antibody
Thermo Fisher Scientific ADRB1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ADRB1, amino acids 181–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far, including three alpha-1 AR subtypes (1A/D, 1B, 1C), three alpha-2 ARs (2A, 2B, 2C), and three beta AR subtypes (1, 2, 3).
ARs are involved in several disease states such as hypertension, cardiac dysfunction, diabetes, glaucoma, depression, and impotence. Beta-1 adrenergic receptors (B1ARs) play roles in development, cardiac function, smooth muscle tone, and metabolism. Mice lacking the B1AR gene often die prenatally, and survivors exhibit abnormal cardiac function. Regulation of cardiac B1AR density by thyroid hormones occurs at the transcriptional level and is modulated by the catecholamine-sensitive adenylyl cyclase system. Evidence for cAMP effects on B1AR regulation involves CREM family transcription factors in transformed cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- BS-0498R_beta-1_Adrenergic_Receptor_P08588-1_Rabbit.svg
- BS-0498R_beta-1_Adrenergic_Receptor_P08588-1_Rabbit_PDP.jpeg
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.