Thermo Fisher Scientific Dnmt3a Polyclonal Antibody
Western blot, IHC, ICC, Flow cytometry 및 ELISA에 적합한 Dnmt3a 폴리클로날 항체입니다. Rabbit IgG로 제작되었으며, 인간, 마우스, 랫트에 반응합니다. Protein A로 정제된 액상 형태로, 1 mg/mL 농도이며 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Dnmt3a, amino acids 26–100 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting, and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with cancer development. Three families of mammalian DNA methyltransferase genes have been identified: Dnmt1, Dnmt2, and Dnmt3.
Dnmt1 is constitutively expressed in proliferating cells, and its inactivation causes global demethylation and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues, and its inactivation does not affect DNA methylation.
Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but downregulated in differentiating ES cells and adult tissues. Mutations in Dnmt3b are associated with ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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