Thermo Fisher Scientific STRAP Monoclonal Antibody (A7H11)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

A7H11

Immunogen

Recombinant protein within human STRAP aa 201-350/350. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:STRAP,uniProtId:Q9Y3F4-1,ncbiNodeId:9606,antigenRange:201-350,antigenLength:350,antigenImageFileName:MA5-50560_STRAP_Q9Y3F4-1_House_mouse.svg,antigenImageFileNamePDP:MA5-50560_STRAP_Q9Y3F4-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3091211

Product Specific Information

Positive control: 293T cell lysate, Jurkat cell lysate, A549 cell lysate, MCF-7 cell lysate, SH-SY5Y cell lysate, human testis tissue.

Predicted band size: 38 kDa

Subcellular Location: Cytoplasm, Nucleus.

Target Information

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.