Thermo Fisher Scientific STRAP Monoclonal Antibody (A7H11)
인간 STRAP 단백질을 인식하는 마우스 단클론 항체로, WB 및 IHC(P)에서 검증됨. 단백질 G 정제, 2 mg/mL 농도의 액상형 제품. 세포 증식 및 TGF-beta 신호 억제 연구에 적합. 연구용으로만 사용 가능.
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Thermo Fisher Scientific STRAP Monoclonal Antibody (A7H11)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A7H11 |
| Immunogen | Recombinant protein within human STRAP aa 201–350/350 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091211 |
Product Specific Information
- Positive control: 293T, Jurkat, A549, MCF-7, SH-SY5Y cell lysates, human testis tissue
- Predicted band size: 38 kDa
- Subcellular location: Cytoplasm, Nucleus
Target Information
STRAP is a 350 amino acid MAP activator with WD-40 repeats localized in both cytoplasm and nucleus. It inhibits TGF-beta signaling and regulates cell proliferation. Stable expression of STRAP activates MAPK/ERK pathway and downregulates p21 (Cip1), leading to retinoblastoma protein hyperphosphorylation. Upregulation may contribute to early colorectal cancer development. STRAP is also involved in U snRNP assembly through association with the SMN complex, critical for intracellular SMN1 distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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