Thermo Fisher Scientific CD103 (Integrin alpha E) Monoclonal Antibody (B-Ly7), PE, eBioscience
인간 CD103(Integrin αE)을 인식하는 B-Ly7 단클론 항체로서 PE 형광표지되어 있습니다. Flow cytometry에 최적화된 사용 조건(5 µL/test)을 제공하며, 인트라피텔리얼 림프구 및 일부 백혈병 세포 표지에 활용됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 12-1038-42
- 판매단위
- pk
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD103 (Integrin alpha E) Monoclonal Antibody (B-Ly7), PE, eBioscience
Thermo Fisher Scientific CD103 (Integrin alpha E) Monoclonal Antibody (B-Ly7), PE, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.25 µg)/test
Publications: View 9 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B-Ly7 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11150242 |
Available Formats
- Unconjugated
- APC
- FITC
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Yellow 610
- NovaFluor Yellow 730
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 780
- Request custom conjugation
Product Specific Information
The B-Ly7 monoclonal antibody reacts with human CD103, the alpha E integrin. CD103 non-covalently associates with integrin beta 7 and is expressed mainly on intraepithelial lymphocytes and a small subset of peripheral lymphocytes. It is also expressed in hairy cell leukemia (HCL) and some chronic B cell lymphocytic leukemias. In vitro stimulation of human T cells with mitogens induces upregulation of CD103.
E-cadherin binds to CD103 and mediates lymphocyte homing to intestinal epithelium.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated for flow cytometry of stimulated normal human peripheral blood cells at 5 µL (0.25 µg) per test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test.
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD103 (ITGAE, Integrin alpha E) is expressed on mucosa-associated T lymphocytes and activated cells. It consists of a 150 kDa alpha chain and a 120 kDa beta chain. CD103 is expressed by 0.5–2% of resting lymphocytes in peripheral blood and lymphoid organs and stains few bone marrow cells. It forms a heterodimer with integrin beta 7, creating an E-cadherin binding integrin known as human mucosal lymphocyte-1 antigen. CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL) and may function in adhesion and activation.
Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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