Thermo Fisher Scientific Human APBA1 Synthetic Peptide
인간 APBA1 단백질의 중심부 12개 아미노산 서열로 구성된 합성 펩타이드. PA5-20525 항체의 차단 실험용으로 사용 가능. PBS 완충액에 0.1% BSA 포함, -20°C 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 12 amino acids near the center of human UROP11.
PEP-0645 can be used as a blocking peptide with polyclonal antibody PA5-20525.
Target Information
The munc-18 interacting protein (Mint) family comprises evolutionarily conserved adaptor proteins involved in membrane transport and organization. Mammals express three isoforms: Mint1, Mint2, and Mint3.
The C-terminal region of these proteins is highly conserved and contains phosphotyrosine-binding (PTB) and PSD-95/DLG-A/ZO-1 (PDZ) domains, which serve as protein interaction modules.
- Mint1 and Mint2: Expressed mainly in the brain; interact with Munc18, a synaptic vesicle fusion component.
- Mint3: Expressed ubiquitously with lowest levels in brain and testis; does not interact with Munc18.
Instead, Mint3 interacts with the Alzheimer’s disease-related amyloid precursor protein (APP) through its PTB and PDZ domains.
It is proposed that Mint3 links APP to transport machinery components, regulating its transport, endocytosis, and metabolism.
Abnormal APP metabolism is associated with early-onset Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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