Thermo Fisher Scientific IRAK2 Monoclonal Antibody (OTI1D4), TrueMAB
IRAK2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 최적화. Human 시료에 반응하며, Lyophilized 형태로 제공. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 362–625 of human IRAK2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
IRAK2 (Interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagement and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
IL-1 induces cellular responses through IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IRAK family members, including IRAK2, play a central role in IL-1R and Toll-like receptor (TLR) mediated inflammatory responses by activating NF-kappa-B.
IRAK2 is expressed in a variety of human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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