Thermo Fisher Scientific IRAK2 Monoclonal Antibody (OTI2B7), TrueMAB
IRAK2 단백질을 인식하는 Mouse monoclonal 항체로 Western blot에 적합합니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. PBS buffer(pH 7.3, 8% trehalose)로 보관하며, -20°C에서 안정적으로 저장 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 362–625 of human IRAK2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagement and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
The pro-inflammatory cytokine IL-1 induces cellular responses through IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IRAK family members, including IRAK2, mediate activation of NF-κB, a key transcription factor regulating inflammatory and immune responses.
IRAK2 is expressed in a variety of human tissues and plays a central role in IL-1R and TLR-mediated signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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