Thermo Fisher Scientific DUSP12 Polyclonal Antibody
DUSP12 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot과 ELISA에 적합하며, 인간 및 생쥐 시료에서 반응. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 130–270 of human DUSP12 (NP_009171.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.54 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805364 |
Product Specific Information
- Immunogen sequence:
LMKTDQLPFE KAYEKLQILK PEAKMNEGFE WQLKLYQAMG YEVDTSSAIY KQYRLQKVTE KYPELQNLPQ ELFAVDPTTV SQGLKDEVLY KCRKCRRSLF RSSSILDHRE GSGPIAFAHK RMTPSSMLTT GRQAQCTSYF I - Positive Samples: Jurkat, A-549
- Cellular Location: Nucleus
Target Information
Dual specificity phosphatases (DUSPs) inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. DUSPs can be divided into six subgroups based on sequence similarity (PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, atypical DUSPs).
DUSP inhibitors may modulate MAPK and cellular responses. Expression and activity of DUSP family members regulate MAPK intensity and duration, influencing physiological responses.
DUSP12 (YVH1, GKAP) contains the consensus DUSP catalytic domain and an extended C-terminal domain of unknown function, possibly related to glucokinase regulation. It is localized in the cytoplasm and nucleus.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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