Thermo Fisher Scientific BAG4 Polyclonal Antibody
Human BAG4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. 세포 사멸 조절 연구에 적합. 연구용으로만 사용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BAG4 (Product # RP-92059) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2856256 |
Product Specific Information
Immunogen sequence:
VHQYESSGTV NNDDSDLLDS QVQYSAEPQL YGNATSDHPN NQDQSSSLPE ECVPSDESTP PSIKKIIHVL EKVQYLEQ
Target Information
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with various apoptosis and growth-related proteins, including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors, and members of the heat shock protein 70 kDa family.
This protein contains a BAG domain near the C-terminus, which can bind and inhibit the chaperone activity of Hsc70/Hsp70. It associates with the death domain of TNF-R1 and DR3, thereby negatively regulating downstream cell death signaling.
Its regulatory role in apoptosis has been demonstrated in epithelial cells undergoing cell death upon loss of integrin-mediated matrix contact.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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