Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI18E8), TrueMAB
인간 PDCD1 단백질을 인식하는 Mouse IgG1 단일클론 항체. Flow Cytometry에 최적화된 TrueMAB 제품으로 높은 특이성과 재현성을 제공. 액상 형태로 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow): Tested dilution 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI18E8 |
| Immunogen | Full length human recombinant protein of human PDCD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APCs). Activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from APCs.
PD-1 binds to ligands PDL-1 and PDL-2, generating inhibitory signals that suppress immune activation in the absence of danger signals like LPS.
PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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