Thermo Fisher Scientific ISG15 Polyclonal Antibody
ISG15 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능. Human에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS 기반 저장용액에 포함되어 있으며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 1–141 of Human ISG15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549338 |
Product Specific Information
- Recommended positive controls: HeLa, rat spleen
- Predicted reactivity: Human (99%), Rhesus Monkey (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. It is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and augmentation of non-MHC-restricted cytotoxicity.
Synthesis is stimulated by IFN-alpha, IFN-beta, or IFN-omega, but not IFN-gamma. ISG15 expression is also induced by overexpression of interferon regulatory factors and by influenza B virus. It is secreted by monocyte, T-lymphocyte, B-lymphocyte, fibroblast, and epithelial cell lines.
Enhancement of NK cell proliferation and induction of IFN-gamma from T cells identify ISG15 as a cytokine-like factor that amplifies immunomodulatory effects of type I interferons. Mutations in ISG15 can result in Immunodeficiency 38 with basal ganglia calcification (IMD38).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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