Thermo Fisher Scientific COMMD10 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, HepG2, HCT116
• Predicted reactivity: Mouse (88%), Rat (89%), Pig (92%), Chicken (80%), Bovine (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The COMMD family represents a group of evolutionarily conserved proteins sharing a common COMM domain at their C-terminus, which mediates protein-protein interactions.
COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein belonging to the COMMD family and contains one COMM domain.
The COMMD10 gene maps to human chromosome 5, which spans approximately 181 million base pairs, comprising nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or the entire chromosome 5 is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
COMMD10 may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may down-regulate activation of NF-kappa-B (PubMed:21778237).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.