Thermo Fisher Scientific FAS Monoclonal Antibody (6D4)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.03 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
SKSVNAQVTD INSKGLELRK TVTTVETQNL EGLHHDGQFC HKPCPPGERK ARDCTVNGDE PDCVPCQEGK EYTDKAHFSS KCRRCRLCDE GHGLEVEINC

Target Information

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily.
FAS also exists in a soluble form that weighs approximately 26 kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases.
The auto-proteolytic processing of the caspases in the complex triggers a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing proliferating signals in normal diploid fibroblast and T cells.
At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. Isoforms lacking the transmembrane domain may negatively regulate apoptosis mediated by the full-length isoform.
The Fas/Fas ligand system plays a role in diseases such as AIDS, hepatitis, and cancer. Induction of apoptosis through the FAS ligand pathway is predominantly involved in antiviral immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.