Thermo Fisher Scientific FAS Monoclonal Antibody (3B9)
FAS 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 3B9). Western blot 및 ELISA에 적합하며, 인간 FAS/CD95 단백질 검출용으로 사용. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B9 |
| Immunogen | FAS (NP_000034, approx. 20–119 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein:
SKSVNAQVTD INSKGLELRK TVTTVETQNL EGLHHDGQFC HKPCPPGERK ARDCTVNGDE PDCVPCQEGK EYTDKAHFSS KCRRCRLCDE GHGLEVEINCTarget Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor in the TNFR superfamily. It also exists in a soluble form (~26 kDa). Upon stimulation, FAS aggregates its intracellular FAS-associated death domains (FADD), forming the death-inducing signaling complex (DISC) and activating caspases, leading to apoptosis.
FAS can activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in proliferative signaling in fibroblasts and T cells. Multiple alternatively spliced isoforms exist, some lacking the transmembrane domain, which may negatively regulate apoptosis. The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a role in antiviral immune responses.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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