Thermo Fisher Scientific APP Monoclonal Antibody (2C12)
APP 단백질을 표적하는 Mouse IgG1 단클론 항체로, Western blot, ELISA, in situ PLA에 적합합니다. 인간 및 랫트 반응성을 가지며, PBS(pH 7.4) 완충액에 보존된 액상 형태로 공급됩니다. 알츠하이머병 연구 등 신경세포 관련 단백질 분석에 유용합니다.
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Thermo Fisher Scientific APP Monoclonal Antibody (2C12)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
| in situ PLA | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C12 |
| Immunogen | APP (AAH04369.1, 19 a.a. approximately 305 a.a) full-length recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EVPTDGNAGL LAEPQIAMFC GRLNMHMNVQ NGKWDSDPSG TKTCIDTKEG ILQYCQEVYP ELQITNVVEA NQPVTIQNWC KRGRKQCKTH PHFVIPYRCL VGEFVSDALL VPDKCKFLHQ ERMDVCETHL HWHTVAKETC SEKSTNLHDY GMLLPCGIDK FRGVEFVCCP LAEESDNVDS ADAEEDDSDV WWGGADTDYA DGSEDKVVEV AEEEEVAEVE EEEADDDEDD EDGDEVEEEA EEPYEEATER TTSIATTTTT TTESVEEVVR EKWYKEVHSG QARWLML
Target Information
Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
APP is important for neurite growth, neuronal adhesion, and axonogenesis.
APP is a 100–140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques — one of the major histopathologic features of Alzheimer’s disease.
Abnormal regulation and processing of APP also play roles in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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