Thermo Fisher Scientific APP Monoclonal Antibody (2C12)

Thermo Fisher Scientific APP Monoclonal Antibody (2C12)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
EVPTDGNAGL LAEPQIAMFC GRLNMHMNVQ NGKWDSDPSG TKTCIDTKEG ILQYCQEVYP ELQITNVVEA NQPVTIQNWC KRGRKQCKTH PHFVIPYRCL VGEFVSDALL VPDKCKFLHQ ERMDVCETHL HWHTVAKETC SEKSTNLHDY GMLLPCGIDK FRGVEFVCCP LAEESDNVDS ADAEEDDSDV WWGGADTDYA DGSEDKVVEV AEEEEVAEVE EEEADDDEDD EDGDEVEEEA EEPYEEATER TTSIATTTTT TTESVEEVVR EKWYKEVHSG QARWLML

Target Information

Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
APP is important for neurite growth, neuronal adhesion, and axonogenesis.
APP is a 100–140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques — one of the major histopathologic features of Alzheimer’s disease.
Abnormal regulation and processing of APP also play roles in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.