Thermo Fisher Scientific APP Monoclonal Antibody (2C12)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

10 µg/mL

-

in situ PLA (PLA)

1:1200

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2C12

Immunogen

APP (AAH04369.1, 19 a.a. approximately 305 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Amyloid Precursor Protein,uniProtId:P05067-1,ncbiNodeId:9606,antigenRange:1-770,antigenLength:770,antigenImageFileName:H00000351-M01_Amyloid_Precursor_Protein_P05067-1_House_mouse.svg,antigenImageFileNamePDP:H00000351-M01_Amyloid_Precursor_Protein_P05067-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: EVPTDGNAGL LAEPQIAMFC GRLNMHMNVQ NGKWDSDPSG TKTCIDTKEG ILQYCQEVYP ELQITNVVEA NQPVTIQNWC KRGRKQCKTH PHFVIPYRCL VGEFVSDALL VPDKCKFLHQ ERMDVCETHL HWHTVAKETC SEKSTNLHDY GMLLPCGIDK FRGVEFVCCP LAEESDNVDS ADAEEDDSDV WWGGADTDYA DGSEDKVVEV AEEEEVAEVE EEEADDDEDD EDGDEVEEEA EEPYEEATER TTSIATTTTT TTESVEEVVR EKWYKEVHSG QARWLML

Target Information

Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimers disease. Abnormal regulation and processing of APP also plays a role in Downs syndrome, early onset familial Alzheimer`s disease, and cerebral hemorrhage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.