Thermo Fisher Scientific IKBIP Polyclonal Antibody
Human IKBIP 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 비결합형 액상 형태입니다. 세포 사멸 및 p53 관련 연구에 활용됩니다.
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Thermo Fisher Scientific IKBIP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human IKBIP. Recombinant protein control fragment (Product #RP-104692). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663800 |
Product Specific Information
Immunogen sequence:
DSTLRNIRTVK RQEEEDLLRV EEQLGSDTKA IEKLEEEQHA LFARDEDLTN KLSDYEPKVE ECKTHLPTIE SAI
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 84%
Target Information
IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. Both APAF1 and IKIP are induced by X irradiation, but their gene products are transcribed in opposite directions. IKIP is considered a p53 target gene, and its expression promotes apoptosis.
IKIP has four known isoforms, three of which traverse the endoplasmic reticulum membrane. Isoform 4 lacks the transmembrane region, resulting in a homogeneous intracellular distribution. IKIP gene products are expressed in vascular endothelial cells, while isoform 4 is also detected in lung, kidney, spleen, thymus, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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