Thermo Fisher Scientific Desmoglein 3 Polyclonal Antibody
Rabbit 폴리클로날 항체로 인간 Desmoglein 3 인식. Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태. 세포 간 접착 연구 및 pemphigus vulgaris 관련 연구에 활용 가능.
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Thermo Fisher Scientific Desmoglein 3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Desmoglein 3 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.38 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735716 |
Product Specific Information
- Positive Control: A431
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, including skin, oral mucosa, and esophagus.
Desmoglein 3 is the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes loss of cell-cell adhesion, clinically manifesting as blisters on skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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