Thermo Fisher Scientific PD-L2 (PDCD1LG2) Monoclonal Antibody (OTI6H10), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Flow Cytometry (Flow)

• Tested Dilution: Assay-Dependent

Product Specifications

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, belongs to the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for PD-1. PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Its expression is upregulated by cytokines such as IL-4, TNF-α, and IFN-γ.

PD-L2 binds PD-1 with a 2–6 times higher affinity than PD-L1, functioning as an inhibitory immune checkpoint molecule that regulates T cell activation and cytokine secretion. Interestingly, PD-L2 can also stimulate T cell proliferation independently of PD-1, indicating additional receptor interactions. One such receptor is repulsive guidance molecule b (RGMb), which plays a role in respiratory tolerance through BMP and/or neogenin signaling pathways.

The human PD-L2 monomer consists of:

• 201 amino acids (extracellular domain)
• 21 amino acids (transmembrane domain)
• 32 amino acids (cytoplasmic domain)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.