Thermo Fisher Scientific ENO1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain
• Predicted reactivity: Mouse (94%), Rat (93%), Xenopus laevis (90%), Chicken (93%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (93%), Guinea pig (95%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Enolase (2-phosphoglycerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. It comprises three subunits: alpha, beta, and gamma.
Non-neuronal Enolase (ENO1) is an isoform composed of two alpha subunits. The ENO1 gene also encodes a shorter monomeric structural lens protein, tau-crystallin.
This multifunctional enzyme plays roles in glycolysis, growth control, hypoxia tolerance, and allergic responses. It may also act as a receptor and activator of plasminogen on the cell surface of leukocytes and neurons, stimulating immunoglobulin production.
ENO1 serves as a diagnostic marker for various tumors and, in its alpha/gamma heterodimeric form, as a marker for hypoxic brain injury and endometriosis.
Antibodies against alpha-enolase are found in sera from patients with cancer-associated retinopathy syndrome (CAR) and are identified as autoantigens in Hashimoto encephalopathy (HE), a rare autoimmune disease associated with Hashimoto thyroiditis (HT).

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.