Thermo Fisher Scientific FOXJ1 Polyclonal Antibody
Human FOXJ1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IP 분석에 적합합니다. 방부제 무첨가 포뮬레이션으로 고순도 정제되어 있으며, FOXJ1 관련 자가면역 및 섬모 형성 연구에 활용 가능합니다.
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- PA580644
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 0.5–2 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the center region of the Human FOXJ1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787936 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human FOXJ1.
Target Information
Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity through repression of NF-κB activity. It also inhibits the humoral immune response in B cells.
FOXJ1 deficiency in B cells leads to spontaneous and enhanced germinal center formation, contributing to pathogenic autoantibody development and heightened immune responses.
Abnormal FOXJ1 expression has been linked to autoimmune and inflammatory diseases.
FOXJ1 is also essential for cilia formation and left-right axis determination by increasing calpastatin expression, which enables basal bodies to anchor to the apical cytoskeleton.
FOXJ1 expression may serve as an early marker for epithelial cell differentiation, recovery, and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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