Thermo Fisher Scientific FRMPD2 Polyclonal Antibody
Human FRMPD2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 적용 가능. Protein A 및 항원 친화 크로마토그래피로 정제. PBS(pH 7) buffer, ProClin 300 함유. FRMPD2의 세포 간 결합 및 tight junction 형성 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:400
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human FRMPD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2787937 |
Product Specific Information
This antibody has specificity for Human FRMPD2.
Target Information
The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, ezrin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occludens-1) domain.
FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL.
FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occludens-1.
Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation.
Other experiments indicate that FRMPD2 is a binding partner to several catenin family members, and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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