Thermo Fisher Scientific FOXJ1 Polyclonal Antibody

Thermo Fisher Scientific FOXJ1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human FOXJ1.

Target Information

Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity through repression of NF-κB activity. It also inhibits the humoral immune response in B cells.
FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations.
Abnormal expression of FOXJ1 may be associated with autoimmune and other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, which is necessary for basal bodies to anchor to the apical cytoskeleton.
FOXJ1 expression may serve as an early marker of epithelial cell differentiation, recovery, and function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.