Thermo Fisher Scientific TrxR1 Polyclonal Antibody

Thermo Fisher Scientific TrxR1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
SCEDGRALEG TLSELAAETD LPVVFVKQRK IGGHGPTLKA YQEGRLQKLL KMNGPEDLPK SYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYG

Target Information

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes has a common stem-loop structure, the SEC insertion sequence (SECIS), necessary for recognition of UGA as a Sec codon rather than a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.