Thermo Fisher Scientific Fibronectin Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Samples: U-87MG, NIH/3T3
• Cellular Location: Extracellular matrix, extracellular space

Immunogen sequence:
QPTDDSCFDP YTVSHYAVGD EWERMSESGF KLLCQCLGFG SGHFRCDSSR WCHDNGVNYK IGEKWDRQGE NGQMMSCTCL GNGKGEFKCD PHEATCYDDG KTYHVGEQWQ KEYLGAICSC TCFGGQRGWR CDNCRRPGGE PSPEGTTGQS YNQYSQRYHQ RTNTNVNCPI ECFMPLDVQA DREDSRE

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also present as a soluble plasma protein.

Fibronectin is composed of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays a critical role in cell adhesion and migration, including processes such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis.

Fibronectin expression is elevated in non-small cell lung carcinoma, where it enhances tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents. The fibronectin gene undergoes alternative splicing, producing up to 20 transcript variants, though not all full-length variants are characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.