Thermo Fisher Scientific Fibronectin Polyclonal Antibody
Western blot, ICC/IF, ELISA에 적합한 폴리클로날 항체로 인간 및 랫트 Fibronectin 검출에 사용. Rabbit IgG 유래, 액상 형태로 제공되며, 고순도 Affinity Chromatography 정제. 세포외기질 및 세포외공간 단백질 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 2169–2355 of human Fibronectin (NP_0020171) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.05 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805184 |
Product Specific Information
- Positive Samples: U-87MG, NIH/3T3
- Cellular Location: Extracellular matrix, extracellular space
Immunogen sequence:
QPTDDSCFDP YTVSHYAVGD EWERMSESGF KLLCQCLGFG SGHFRCDSSR WCHDNGVNYK IGEKWDRQGE NGQMMSCTCL GNGKGEFKCD PHEATCYDDG KTYHVGEQWQ KEYLGAICSC TCFGGQRGWR CDNCRRPGGE PSPEGTTGQS YNQYSQRYHQ RTNTNVNCPI ECFMPLDVQA DREDSRE
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also present as a soluble plasma protein.
Fibronectin is composed of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays a critical role in cell adhesion and migration, including processes such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis.
Fibronectin expression is elevated in non-small cell lung carcinoma, where it enhances tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents. The fibronectin gene undergoes alternative splicing, producing up to 20 transcript variants, though not all full-length variants are characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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