Thermo Fisher Scientific Phospho-KSR1 (Thr425) Polyclonal Antibody
KSR1 단백질의 Thr425 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot에 최적화되어 있으며, 인간, 마우스, 랫트 시료에 반응. PBS/glycerol buffer에 보관되며 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KSR1 (Accession Q8IVT5), corresponding to amino acid residues around phosphorylated Thr425 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816565 |
Product Specific Information
This antibody detects endogenous levels of KSR1 only when phosphorylated at Thr425.
Target Information
KSR1 is part of a multiprotein signaling complex that promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, KSR1 acts as a MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF. Upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, it dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). It promotes activation of MAPK1 and/or MAPK3 in response to EGF and cAMP. The physiological relevance of its kinase activity remains uncertain. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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