Thermo Fisher Scientific GRK1 Polyclonal Antibody
GRK1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 고순도 친화 크로마토그래피로 정제된 액상 항체입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific GRK1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–160 of human GRK1 (NP_002920.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.19 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855199 |
Product Specific Information
Immunogen sequence:
MDFGSLETVV ANSAFIAARG SFDGSSSQPS RDKKYLAKLK LPPLSKCESL RDSLSLEFES VCLEQPIGKK LFQQFLQSAE KHLPALELWK DIEDYDTADN DLQPQKAQTI LAQYLDPQAK LFCSFLDEGI VAKFKEGPVE IQDGLFQPLL QATLAHLGQA
Target Information
GRK1 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of Ser/Thr protein kinases.
It mediates rapid desensitization of rod photoreceptors to light by phosphorylating rhodopsin, leading to its deactivation.
Defects in GRK1 are associated with Oguchi disease 2 (stationary night blindness, Oguchi type-2).
GRK1 can be phosphorylated by PKA, reducing its ability to phosphorylate rhodopsin in vitro. This phosphorylation may occur in vivo in the dark when cAMP levels in photoreceptor cells are elevated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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