Thermo Fisher Scientific TACC3 Polyclonal Antibody
Rabbit polyclonal antibody against human TACC3 (aa 790–830). Suitable for IHC(P) and ICC/IF applications. Provided unconjugated in liquid form at 1 mg/mL concentration. Recommended storage at 4°C short term or -20°C long term.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 790–830 of Human TACC3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803259 |
Target Information
TACC1 is located on the 8p11 chromosomal region, which is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1, whose expression is enhanced in most breast cancer tumors.
TACC family members (TACC1, TACC2, and TACC3) map closely to the corresponding FGFR1, FGFR2, and FGFR3 genes on chromosomes 4, 8, and 10. Since they are phylogenetically related, TACC and FGFR are proposed to have similar roles in cell growth and differentiation.
TACC1 contains a conserved C-terminal region similar to the Drosophila homolog D-TACC, which is necessary for normal spindle function. Mammalian TACC proteins appear to interact with centrosomes and microtubules in a similar manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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