Thermo Fisher Scientific JAK2 Monoclonal Antibody (1C1)
JAK2 단백질을 인식하는 Mouse IgG1 단클론 항체로, 인간 시료에 반응합니다. Western blot 및 ELISA에 적합하며, 재조합 JAK2(745-955aa) 단편을 면역원으로 사용했습니다. 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C1 |
| Immunogen | Purified recombinant fragment of JAK2 (745–955aa) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10980515 |
Product Specific Information
MA5-15632 targets JAK2 in indirect ELISA and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of JAK2 (745–955aa) expressed in E. coli.
MA5-15632 detects JAK2, which has a predicted molecular weight of approximately 130.6 kDa.
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is mutated in polycythemia vera.
JAK2 contains the catalytic domain (JH1) and mediates phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to regulate gene transcription.
JAK2 is essential for IFN-γ receptor complex initiation, while JAK1 acts as an amplifier.
Mutations in JAK2 are associated with disorders such as Budd-Chiari syndrome, polycythemia vera, thrombocythemia 3, myelofibrosis, and acute myelogenous leukemia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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